Prezista: Uses, Dosage, Side Effects, Warnings - Drugs.com (2024)

Generic name: darunavir [da-ROON-a-veer]
Drug class: Protease inhibitors

Medically reviewed by Philip Thornton, DipPharm. Last updated on Jun 7, 2022.

What is Prezista?

Prezista is a protease (PRO-tee-ayz) inhibitor antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body.

Prezista is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS).

Prezista must be given in combination with ritonavir and other antiviral medications and should not be used alone.

Prezista is not a cure for HIV or AIDS.

Warnings

Stop taking Prezista and call your doctor right away if you have a severe skin reaction: fever, burning or redness in your eyes, mouth sores, or a skin rash that spreads and causes blistering and peeling.

Prezista can cause serious liver problems. Call your doctor if you have upper stomach pain, loss of appetite, tiredness, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

Stop taking Prezista and call your doctor right away if you have a severe skin reaction: fever, burning or redness in your eyes, mouth sores, or a skin rash that spreads and causes blistering and peeling.

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

Before taking this medicine

You should not take Prezista if you have severe liver disease.

Some drugs should not be used with Prezista. Your treatment plan may change if you also use:

• alfuzosin;

• cisapride;

• colchicine (in people with liver or kidney disease);

• dronedarone;

• elbasvir and grazoprevir;

• lurasidone;

• naloxegol;

• pimozide;

• rifampin;

• sildenafil (Revatio, for pulmonary arterial hypertension);

• St. John's wort;

  See Also

  Medications - non-steroidal anti-inflammatory drugs

• triazolam or oral midazolam;

• heart medicine - ivabradine, ranolazine;

• cholesterol medication - lomitapide, lovastatin, simvastatin; or

• ergot medicines - dihydroergotamine, ergotamine, methylergonovine.

To make sure Prezista is safe for you, tell your doctor if you have ever had:

• liver disease (especially hepatitis B or C);

• diabetes;

• a bleeding disorder such as hemophilia; or

• an allergy to sulfa drugs.

To prevent HIV in a newborn baby, use all medications to control your infection during pregnancy. Your name may be listed on an antiviral pregnancy registry.

Prezista can make hormonal birth control less effective, including birth control pills, injections, implants, skin patches, and vagin*l rings. To prevent pregnancy while using Prezista, use a barrier form of birth control: condom, diaphragm, cervical cap, or contraceptive sponge.

Women with HIV should not breastfeed. The virus can pass to your baby in your breast milk.

Prezista and ritonavir should not be given to a child younger than 3 years old, or a child who weighs less than 22 pounds (10 kilograms).

How should I take Prezista?

Take Prezista exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Prezista must be taken together with ritonavir and other antiviral medications.

Darunavir doses are based on weight in children. Your child's dose may change if the child gains or loses weight.

Prezista works best if you take it with food. Take Prezista and ritonavir together at the same time every day.

Swallow the Prezista tablet whole and do not crush, chew, or break it.

Shake the oral suspension (liquid). Measure a dose with the supplied syringe or a dose-measuring device (not a kitchen spoon).

You will need frequent medical tests.

Use all HIV medications as directed. Do not change your dose or stop using a medicine without your doctor's advice. Remain under the care of a doctor.

Store at room temperature away from moisture and heat.

Dosing information

Usual Adult Dose of Prezista for HIV Infection:

Usual Pediatric Dose for HIV Infection:

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Always take Prezista and ritonavir together.

Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Prezista?

Taking Prezista will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Ask your doctor how to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe.

Prezista side effects

Get emergency medical help if you have signs of an allergic reaction to Prezista (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

• a skin rash, no matter how mild;

• high blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor; or

• signs of liver or pancreas problems - loss of appetite, upper stomach pain (that may spread to your back), nausea or vomiting, fast heart rate, dark urine, jaundice (yellowing of the skin or eyes).

Darunavir affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have:

• signs of a new infection - fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;

• trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or

• swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.

Common Prezista side effects may include:

• nausea, vomiting, diarrhea, stomach pain;

• headache;

• rash; or

• changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Prezista?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

If you also take didanosine (Videx), take your Prezista dose 2 hours before or 1 hour after you take didanosine.

Many drugs can interact with darunavir, and some drugs should not be used at the same time. Tell your doctor about all other medicines you use. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Frequently asked questions

• What drugs are contained in the HIV treatment Symtuza?

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Prezista only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circ*mstances.

Medical Disclaimer

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